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Posts tagged ‘virus’

A Long Time To Die

Dying Takes It Out of You – Book One of the Madonna Diaries
by S.S. Bazinet. Reviewed by Gabriel Constans.

513xwn-wYJLMental gymnastics, emotional turmoil, and brotherly love, all add weight to this dystopian thriller. Dying Takes It Out of You is set in the near future, when a virus has been deployed by terrorists, and the entire world is threatened. Dory is one of those infected, who believes he’d rather die than live in this shit hole that has become his life. His brother Milton, a scientist and doctor, has other ideas for Dory, and tries to save him by finding a cure at all costs. It may cost them everything.

Ms. Bazinet has taken a terrifying world in the near future, and turned it into a philosophical and ideological tale about understanding, family, and what is worth living for, without giving up an iota of fear or suspense. The beginning is intentionally misleading, making readers believe that the pursuer is evil, and the narrator (Dory) is running for his life. The sudden switch in who is in danger, and the shift from which person is good, and who is bad, is well executed.

In the process of Milton’s heroics to save his brother, who craves blood, is afraid he’ll go crazy, and will most likely die a horrible death within weeks, Dory describes his experience. “Sometimes a person doesn’t know how strong they are until they keep dying and coming back. A few days in, Milton said that I was having a convulsion and then clunk, I was dead again. The old vessel in my chest decided it had had enough and just stopped working in mid fit. Even Milton was surprised. Most people take longer to kill.”

This fantasy, by S. S. Bazinet, explores the depths a loved one (in this case his twin brother) will take to keep them alive. The world she creates is not that distant, or foreign, and has a strong connection with its surroundings. Memories that Dory has of an abusive father, and kind mother, are also interspersed with lucid dreams and conversations with Thomas, an individual known as one of the Watchers. These dialogues provide Dory with insight and hope, and make Dying Takes It Out of You all the better.

Viruses Can Kill Cancer?

From Technology Review.

Biomedicine Engineered Viruses Selectively Kill Cancer Cells: The experimental therapy could ultimately serve as a seek-and-destroy treatment for metastatic cancer.

Wednesday, August 31, 2011 By Alla Katsnelson.

A single injection of a virus that has been genetically engineered to kill cancer cells can reliably infect tumors and leave healthy tissue unharmed, according to an early stage trial of 23 patients with metastatic cancers. The findings help lay the groundwork for a new type of cancer medicine using cancer-killing viruses.

Researchers injected different doses of the virus into patients with different types of metastatic cancers. After eight to 10 days, they biopsied tumor tissue from each patient and found that the virus was replicating itself in the tumors of seven of the eight patients who had received the highest dose, with no serious side effects. Several weeks after the injection, tumors in about half of the patients seemed to stop growing, and shrunk in one patient. The study is published today in the journal Nature.

While the study is not the first to test a cancer-killing viral therapy, it is the first to thoroughly document the behavior of the virus in patients’ biopsy tissue. The results confirm that viruses can be used to selectively target these cells.

One reason tumors can grow unchecked is that they suppress the immune system. However, this also makes tumor cells more susceptible to viruses, which replicate inside the infected cell until it bursts. Physicians have known for more than a century that viral infection slows tumor growth, and in recent years they’ve used molecular biology techniques to reëngineer more effective cancer-killing viruses.

Most such viruses now in trials are injected directly into the tumor. But what researchers really need is a therapy that could be injected into the bloodstream and seek out metastasized cancer cells throughout the body, says David Kirn, chief executive officer at Jennerex, the San Francisco-based biotech company that funded the study.

Read entire story at TECHNOLOGY REVIEW.

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